A new three-order piecewise function was used to smoothen the model of Support Vector Machine( SVM) and a Third-order Piecewise Smooth SVM( TPSSVM) was proposed. By theory analyzing, approximation accuracy of the smooth function to the plus function is higher than that of the available. When dealing with the multi-class problem, a coding method of multi-class classification based on one-against-rest was proposed. Principal Component Analysis( PCA) was employed to extract the main features of face image set, and multi-class classification of (...) smooth SVM was used for face recognition. The experimental results on ORL and FERET face databases show that the recognition rate of smooth SVM for multi-class classification is better than the traditional identification methods. (shrink)

The current study presents an integrative model examining the double-edged sword effect of unethical pro-organizational behavior (UPB) from the perspective of the actors. Drawing on the moral self-regulation perspective and psychological entitlement literature, we propose that employees who engage in UPB may experience an increase in moral deficits and psychological entitlement, resulting in increased organizational citizenship behavior (OCB) and decreased work effort, respectively. We further propose that moral attentiveness strengthens the positive relationship between UPB and moral deficits but weakens the (...) positive relationship between UPB and psychological entitlement. Moreover, the strength of the indirect effects of employee UPB on OCB and work effort is also contingent upon employees’ moral attentiveness. The hypothesized moderated mediation model is supported by a multisource and time-lagged research design based on a sample of 256 supervisor–subordinate dyads. Key theoretical and practical implications and future research directions are discussed. (shrink)

To investigate the effects of left-behind children’s empathy and coping styles on school adjustment, 605 left-behind children in the third grade from three rural elementary schools in Suzhou, Anhui Province were selected to complete the Chinese version of the Interpersonal Reaction Index Scale, the Coping Style Scale, and the School Adjustment Behavior Scale for Primary and Secondary School Students. The results showed that emotional empathy positively predicted children’s social competence, and negatively predicted children’s antisocial behavior; cognitive empathy positively predicted children’s (...) social competence; the role of positive coping styles mediated the relationship between cognitive empathy and social competence, and that between cognitive empathy and antisocial behavior; negative coping styles mediated the relationship between cognitive empathy and antisocial behavior; both positive and negative coping styles mediated the relationship between emotional empathy and social competence, and that between emotional empathy and antisocial behavior. The findings of the study are valuable for understanding the relationship between empathy and school adjustment, which also helps to enhance the school adjustment of left-behind children. (shrink)

Drawing on the social exchange theory, this study adopted a cross-level framework to investigate the influence of consumer group communication on consumer product image perception and brand memory. In addition, this paper examined the moderating role of consumer group involvement in the cross-level relationship between consumer group communication and consumer product image perception. Based on a sample of 116 groups and 530 consumers, results revealed that consumer group communication has a significant positive influence on brand memory formation across levels. Consumer (...) product image perception plays a cross-layer mediated role between consumer group communication and brand memory. Group involvement plays a cross-level negative moderating role between consumer group communication and consumer product image perception, and moderates the mediating role of consumer product image perception between consumer group communication and consumer brand memory across different levels. Finally this paper discussed implications for research and practice. (shrink)

Despite research supporting the efficacy of family therapy for adolescent depression, little research has been done to clarify the therapeutic variables that Chinese families with depressed adolescents consider helpful in family therapy. This study explored Chinese depressed adolescents’ and their parents’ perceptions of the factors promoting improvement in family therapy. Twelve Chinese families with one adolescent child fulfilling the criteria for major depressive disorder were recruited. A total of 134 family therapy sessions were conducted by 4 therapists. After therapy, semi-structured (...) interviews about the clients’ perceptions of the helpful and effective aspects of therapy were conducted. Thematic analysis was used to analyze the transcribed dialogues. Five overarching themes emerged: factors supporting therapeutic alliance formation, the therapist’s systemic attitude, systemic therapy direction, effective systemic therapy techniques and strategies for dealing with current issues. A trustworthy therapy alliance with a competent and supportive therapist helped depressed adolescents improve by facilitating the expression of their emotions; exploring family interactions, beliefs and emotion flows related to their symptoms; promoting their self-development; and activating their resources. The families valued the respectfulness of the therapists and their collaborative and nonauthoritative approach. Adolescents’ academic difficulties and crises received special attention. The possible clinical implementations of our findings in the design of family therapy strategies for depressed Chinese adolescents are discussed. (shrink)

Meiotic defects cause abnormal chromosome segregation leading to aneuploidy in mammalian oocytes. Chromosome segregation is particularly error‐prone in human oocytes, but the mechanisms behind such errors remain unclear. To explain the frequent chromosome segregation errors, recent investigations have identified multiple meiotic defects and explained how these defects occur in female meiosis. In particular, we review the causes of cohesin exhaustion, leaky spindle assembly checkpoint (SAC), inherently unstable meiotic spindle, fragmented kinetochores or centromeres, abnormal aurora kinases (AURK), and clinical genetic variants (...) in human oocytes. We mainly focus on meiotic defects in human oocytes, but also refer to the potential defects of female meiosis in mouse models. (shrink)

ObjectivePregnancy leads to long-lasting changes in brain structure for healthy women; however, little is known regarding alterations in the cortical features of pregnant women with malformed fetuses. Isolated clefts of the lip and/or palate (ICL/P) are the most common congenital anomaly in the craniofacial region, which is highly gene-associated. We speculated that pregnant women carrying fetuses with ICL/P may have associated risk genes and specific brain changes during pregnancy.MethodsIn this study, we investigated T1-weighted brain magnetic resonance imaging data from 48 (...) pregnant women: 24 women carrying fetuses with ICL/P (ICL/P group) and 24 women carrying normal fetuses (normal controls), then explored intergroup differences in gray matter volume (GMV), cortical thickness (CT) and cortical complexity (gyrification).ResultsCompared with controls, the ICL/P group had decreased total intracranial volume (TIV) than normal controls; besides, they exhibited increased GMV in the left cuneus, decreased GMV in the right superior temporal gyrus; increased CT in the left precuneus and left superior parietal gyrus, decreased CT involving parsopercularis, fusiform, middle temporal in the left hemisphere and supramarginal, precentral gyrus (PreCG) in the right hemisphere; increased gyrification in the left insula and PreCG, the left middle temporal, and the right supratemporal gyrus.ConclusionPregnant women with ICL/P fetuses had brain morphology changes involving language, auditory, vision, and sensory cortex, which may be their special brain changes compared to normal pregnant women. This study may provide clues for the early detection of fetuses with ICL/P, and be vital for preconception and prenatal counseling with non-invasive methods. (shrink)

The emergence of any idea must have a deep-seated social background, and at the same time there must be an intellectual source that cannot be neglected. That is to say, every idea must have as its foundation some piece of intellectual material that has been handed down by people of the past. Lao Zi once said: "All Things Under Heaven [tianxia wanwu] are born of Existence [you]; Existence [you] is born of Nonexistence [wu]." This does not mean that existence is (...) born out of nothingness or nonexistence [xuwu]. In reality, what Lao Zi meant by "Nonexistence" [wu] is actually itself a kind of existence; but because its state of existence [cunzai zhuangtai] is different from that of Existence [you], it is called "Nonexistence" [wu] instead. This difference of the states of existence lies in [the following]: Existence has form, and therefore can be sensed; Non-existence has no form, and therefore cannot be sensed. In the chapter "Fei ming" of the book Mo Zi there is the passage that says: "Something can be heard, something can be seen; we call it Existence; something cannot be heard, cannot be seen; we call it Destruction [wang] [wu]." Even though the meanings of "Existence" and "Nonexistence" here are different from those in Lao Zi's idea, we may still trust that the general interpretation of "Existence" and "Nonexistence" here would still meet with Lao Zi's approval. In Lao Zi's view, even though Nonexistence cannot be comprehended through sensation, it can be grasped by metaphysical and mystical "vision." Lao Zi's expression that "Existence is born of Nonexistence" was not only an expression of his viewpoint on the question of the origin of "all things under heaven," but also a general rule for us to follow in examining the evolution of human thought. On the one hand, it demonstrates that every single idea must have its source, its intellectual origin; on the other hand, it points out that the idea that serves another as intellectual source may be hidden, not overt, at times. On the surface, some ideas may appear to have no "genealogical origin"—water without a fountainhead or well spring, and yet, perhaps, if we were to conduct further investigation and research, we would discover that they all have some ancient source, some long-forgotten well spring. That is precisely what this essay hopes to accomplish—to attempt to explore in a preliminary way the ancient source of Lao Zi's thought. (shrink)

The corner space, an important area of underground commercial streets, not only converts space functions but also exerts a great impact on the space atmosphere by transforming the environmental quality of the commercial street space. Based on corner space investigations of several underground commercial streets in China, this paper constructs a realistic scene model using virtual reality technology and screens. This paper classifies the corner space elements of underground commercial streets through preliminary experiments. Based on the conclusions, different morphological models (...) of the corner space were constructed by orthogonal experiments and virtual reality technology combined with psychology. A semantic differential was used to quantitatively evaluate and analyze the spatial experience cognition of the subjects. This enabled an analysis of the of underground commercial street corners’ relationship to the component elements and the visitors’ psychological perception of their spatial form. (shrink)

Fraud can cause severe financial losses and affect the physical and mental health of victims. This study aimed to explore the manipulative characteristics of fraudsters and their relationship with other psychological variables. Thirty-four fraudsters were selected from a medium-security prison in China, and thirty-one healthy participants were recruited online. Both groups completed an emotional face-recognition task and self-report measures assaying emotional manipulation, psychopathy, emotion recognition, and empathy. Results showed that imprisoned fraudsters had higher accuracy in identifying fear and surprise faces (...) but lower accuracy in identifying happiness than controls. Significantly lower scores on non-prosocial factors on the Managing the Emotions of Others scale were found for imprisoned fraudsters, relative to controls. Imprisoned fraudsters had low scores in the assessment of psychopathy than the control group, especially Factor 1. For empathy, imprisoned fraudsters had significantly higher scores in perspective-taking than controls. Correlation analyses revealed that psychopathic traits were positively correlated with non-prosocial factors in both groups. However, the relationships between emotional manipulation and emotional recognition and empathy were not consistent across the groups. The results suggest that fraudsters may pretend to be as prosocial as healthy controls, who had lower antisocial tendencies, normal empathy ability, and would like to manipulate others’ emotions positively during social interaction. (shrink)

Ongoing electroencephalography signals are recorded as a mixture of stimulus-elicited EEG, spontaneous EEG and noises, which poses a huge challenge to current data analyzing techniques, especially when different groups of participants are expected to have common or highly correlated brain activities and some individual dynamics. In this study, we proposed a data-driven shared and unshared feature extraction framework based on nonnegative and coupled tensor factorization, which aims to conduct group-level analysis for the EEG signals from major depression disorder patients and (...) healthy controls when freely listening to music. Constrained tensor factorization not only preserves the multilinear structure of the data, but also considers the common and individual components between the data. The proposed framework, combined with music information retrieval, correlation analysis, and hierarchical clustering, facilitated the simultaneous extraction of shared and unshared spatio-temporal-spectral feature patterns between/in MDD and HC groups. Finally, we obtained two shared feature patterns between MDD and HC groups, and obtained totally three individual feature patterns from HC and MDD groups. The results showed that the MDD and HC groups triggered similar brain dynamics when listening to music, but at the same time, MDD patients also brought some changes in brain oscillatory network characteristics along with music perception. These changes may provide some basis for the clinical diagnosis and the treatment of MDD patients. (shrink)

l‐Lactate is emerging as a crucial regulatory nexus for energy metabolism in the brain and signaling transduction in synaptic plasticity, memory processes, and drug addiction instead of being merely a waste by‐product of anaerobic glycolysis. In this review, the role of lactate in various memory processes, synapse plasticity and drug addiction on the basis of recent studies is summarized and discussed. To this end, three main parts are presented: first, lactate as an energy substrate in energy metabolism of the brain (...) is described; second, lactate as a novel signaling molecule in synaptic plasticity, neural circuits, memory, and drug addiction is described; and third, in light of the above descriptions, it is plausible to speculate that lactate is predominantly a signaling molecule in specific memory processes and partly acts as an energy substrate. The future perspective in lactate signaling involving microglia and associated precise signaling pathways in the brain is highlighted. (shrink)

Objective: This meta-analysis evaluated the efficacy of acupuncture in improving cognitive impairment of post-stroke patients.Design: Randomized controlled trials investigating the effects of acupuncture compared with no treatment or sham acupuncture on post-stroke cognitive impairment before December 2019 were identified from databases. The literature searching and data extracting were independently performed by two investigators. Study quality was assessed using the Cochrane Handbook for Systematic Reviews of Interventions. Meta-analyses were performed for the eligible RCTs with Revman 5.3 software.Results: Thirty-seven RCTs were included (...) in this meta-analysis. Merged Random-effects estimates of the gain of MMSE or MoCA were calculated for the comparison of acupuncture with no acupuncture or sham acupuncture. Following 2–8 weeks of intervention with acupuncture, pooled results demonstrated significant effects of acupuncture in improving PSCI assessed by MMSE or MoCA.Conclusion: The results suggest that acupuncture was effective in improving PSCI and supported the needs of more rigorous design with large-scale randomized clinical trials to determine its therapeutic benefits. (shrink)

Previous research has mostly focused on Internet use behaviors, such as usage time of the Internet or social media after individuals experienced offline social exclusion. However, the extant literature has ignored online response behaviors, such as online review responses to social exclusion. To address this gap, drawing on self-protection and self-serving bias, we proposed three hypotheses that examine the effect of offline social exclusion on online reviews, which are verified by two studies using different simulating scenarios with 464 participants. The (...) results show that when individuals are socially excluded offline, regardless of where the exclusion comes from, they will be more likely to give negative online reviews. In addition, brand awareness moderates the effect of offline social exclusion on online reviews. Specifically, if the brand is less known, compared with social inclusion, offline social exclusion will lead individuals to give more negative online reviews; conversely, for well-known brands, no significant difference exists in the online reviews between social exclusion and inclusion. (shrink)

The joint multifractal analysis is usually conducted in two different variables for their cross-correlations but rarely used for two records of one variable collected at two different places. It is important for the detection of change in multifractality in space. Besides, the cross-correlations in two analyzed series make the analysis of sources of joint multifractality difficult. There are few studies on the source of joint multifractality. We focus on the two issues for two level records at pairs of adjacent sites (...) along one river and carry out an extension of our previous work which is about the single multifractality of one record with the same data set. The data set is collected from 10 observation stations of a northern China river and contains about two million high-frequency river level records. Results of joint multifractal analysis via multifractal detrended cross-correlation analysis show that the change in joint multifractality at pairs of adjacent sites caused by weak cross-correlations can be detected by comparing the single generalized Hurst exponent with the joint scaling exponent function and reveal the effects of human activities on joint multifractality. This analysis provides an approach for detecting the change in multifractality. Following the idea of our previous work, two robust hypothesis tests via a set of pairs of surrogate series are proposed for the source testing of joint multifractality. The analysis of the effects of cross-correlations is carried out via a proposed simultaneously half-shifting technique which can both minimize the cross-correlations between original series and make full use of records. Results of source analysis show not only the effects of autocorrelations in series and probability distribution of river levels but also the effects of cross-correlations between series. (shrink)

The human brain shows neuroplastic adaptations induced by motor skill training. However, the description of the plastic architecture of the whole-brain network in resting-state is still limited. In the present study, we aimed to detect how motor training affected the density distribution of whole-brain resting-state functional connectivity (FC) brain in fast-ball student-athletes using resting-state functional magnetic resonance imaging (fMRI) data of student-athletes (SA), and non-athlete healthy controls (NC). The voxel-wise data-driven graph theory approach, namely global functional connectivity density (gFCD) mapping (...) was applied. The results showed that the SA group exhibited significantly decreased gFCD in brain regions centered at left triangular part of inferior frontal gyrus (IFG), extending to opercular part of left IFG and middle frontal gyrus (MFG) compared with NC group. The findings supported the idea of an increased neural efficiency of athletes’ brain in the brain regions associated with attentional-motor modulation and executive control. Furthermore, the behavioral results demonstrated that in the SA group, faster executive control reaction time was associated with smaller gFCD values in left IFG. The findings implied that the motor skill training would decrease the numbers of FC in IFG to accelerate the execution control with high attentional demands, and focus the attention to the target detection the athletes are interested in. (shrink)

Poverty alleviation through tourism is an important way for China to achieve targeted poverty alleviation and win the battle of poverty alleviation. As a region with deep poverty and great difficulty in poverty alleviation, whether tourism development has injected key impetus into ethnic minority areas needs to be tested by both qualitative analysis and quantitative measurement. This paper takes eight ethnic provinces in China as an example to conduct an empirical study. Based on the Data Envelopment Analysis -BCC model and (...) Malmquist index, it evaluates the tourism investment and tourism poverty alleviation efficiency of the ethnic regions in the two stages of tourism poverty alleviation, and analyzes them by classification. The results of the study show: The pure technical efficiency in the first stage is relatively high, but the total factor productivity of each region is declining; The pure technical efficiency in the second stage is also relatively high, but the scale efficiency is low, and the change rate of total factor productivity of the provinces in China has increased significantly; The “double high” type includes Guangxi, Inner Mongolia, and Guizhou, and the “double low” type includes Qinghai, Yunnan, Tibet, Xinjiang, and Ningxia. The results of the study generally show that tourism poverty alleviation has brought about the improvement of the living standards of residents and the development of local economy, but the efficiency of tourism poverty alleviation needs to be improved. On this basis, the article puts forward corresponding improvement measures, in order to further help the ethnic minority areas get rid of poverty in a comprehensive way by promoting the efficient and sustainable development of tourism. (shrink)

Depression is a common mental health illness worldwide that affects our quality of life and ability to work. Although prior research has used EEG signals to increase the accuracy to identify depression, the rates of underdiagnosis remain high, and novel methods are required to identify depression. In this study, we built a model based on single-channel, dry-electrode EEG sensor technology to detect state depression, which measures the intensity of depressive feelings and cognitions at a particular time. To test the accuracy (...) of our model, we compared the results of our model with other commonly used methods for depression diagnosis, including the PHQ-9, Hamilton Depression Rating Scale, and House-Tree-Person drawing test, in three different studies. In study 1, we compared the results of our model with PHQ-9 in a sample of 158 senior high students. The results showed that the consistency rate of the two methods was 61.4%. In study 2, the results of our model were compared with HAM-D among 71 adults. We found that the consistency rate of state-depression identification by the two methods was 63.38% when a HAM-D score above 7 was considered depression, while the consistency rate increased to 83.10% when subjects showed at least one depressive symptom. In study 3, 68 adults participated in the study, and the results revealed that the consistency rate of our model and HTP drawing test was 91.2%. The results showed that our model is an effective means to identify state depression. Our study demonstrates that using our model, people with state depression could be identified in a timely manner and receive interventions or treatments, which may be helpful for the early detection of depression. (shrink)

Background and aimDuring the COVID-19 pandemic, an Internet-Mindfulness-Based Stress Reduction program was delivered and may be better than an in-person approach. Our study evaluated the effects of iMBSR intervention on mental health, self-efficacy, and body image in women with breast cancer in Taiwan.Materials and methodsSixty-seven women with breast cancer were allocated to a 6-week iMBSR program or a waitlist control group, without heterogeneity between group characteristics. Patients from both groups were measured at baseline and postintervention using three scales: Depression, Anxiety, (...) and Stress Scale, General self-efficacy scale, and Body Image Scale. Descriptive dataset analysis, paired t-test, and Student’s t-test were used to evaluate the data.ResultsAlthough iMBSR did not significantly improve depression and stress between groups, iMBSR could improve anxiety with medium effect sizes. Significant benefits were found for body image and self-efficacy, with large effect sizes.ConclusionOur preliminary study supports iMBSR as a program that can improve mental health, body image, and self-efficacy in women with breast cancer. During the COVID-19 pandemic, medical professionals can use Internet-based clinical health education. (shrink)

Electroacupuncture (EA) and electroconvulsive therapy (ECT) are often used in the management of schizophrenia. This study sought to determine whether additional EA and ECT could augment antipsychotic response and reduce related side effects. In this retrospective controlled study, 287 hospitalized schizophrenic patients who received antipsychotics (controls, n = 50) alone or combined with EA (n = 101), ECT (n = 55) or both (EA+ECT, n = 81) were identified. EA and ECT were conducted for 5 and 3 sessions per week, (...) respectively, with a maximum of 12 sessions for ECT during hospitalization. The Scale for the Assessment of Positive Symptoms (SAPS) and Scale for the Assessment of Negative Symptoms (SANS) were used to assess the severity of psychotic symptoms. Clinical response on SAPS and SANS, weight gain, and adverse events were compared. Survival analysis revealed that the ECT and EA+ECT groups had markedly greater clinical response rate than controls on SAPS [72.7% and 90.1% vs. 64.0%; relative risk (RR), 1.974 and 2.628, respectively, P ≤ 0.004] and on SANS (67.3% and 70.4% vs. 42.0%; RR, 1.951 and 2.009, respectively, P ≤ 0.015). A significantly greater response rate on SANS than controls was also observed in the EA group (64.4% versus 42.0%; RR = 1.938, P = 0.008). EA-containing regimens remarkably reduced weight gain and incidences of headache, insomnia, dry mouth, and electrocardiographic abnormalities. These results suggest that EA and ECT can serve as additional treatment for enhancing antipsychotic response and reduce the side effects in hospitalized patients with schizophrenia. (shrink)

ε-support vector regression (ε-SVR) as a constrained minimization problem can be converted into an unconstrained convex quadratic programming. Smooth function is the essence of the ε-smooth support vector regression (ε-SSVR). In this paper, a new rotated hyperbola function is proposed to replace the ε-insensitive loss function. The ε-rotated hyperbola smooth support vector regression (ε-RHSSVR) model is presented. Theoretical analyses show that the derived smooth function has improved approximation precision compared with other smooth approximate functions. The Newton-Armijo algorithm is applied to (...) train the new model. Numerical results and comparisons are given to demonstrate the effectiveness and speed of the method. -/- . (shrink)

This article puts forward a novel class of Bézier smooth semi-supervised support vector machines(BS4VMs) for classification. As is well known, semi-supervised support vector machine is introduced for dealing with quantities of unlabeled data in the real world. Labeled data is utilized to train the algorithm and then adapting it to classify the unlabeled data. However, the objective semi-supervised function is not differentiable globally. It is required to endure heavy burden in solving two quadratic programming problems with inversion matrix operation. To (...) solve this problem, the interpolation Bézier functions for replacing the non-smooth term have been investigated. Firstly, the development of the novel BS4VMs classifier is introduced. Then, the non-linear model and convergence analysis are presented. To show how the BS4VMs can be practically implemented, experiments on synthetic and real data sets are offered. The theoretical analysis and experiments comparisons clearly illustrate the BS4VMs are superior to the proposed methods in both cross-validation classification accuracy and calculating time. (shrink)

A new smooth method for solving the support vector machine classification (SVC) is presented. Since the objective function of the unconstrained SVC is non-smooth, we apply the smooth technique and replace the SVC function with Bézier function and get a class of Bézier smooth support vector machines (BSSVM). The fast Newton-Armijo algorithm is used to solve the BSSVM. Theoretical analysis and numerical results illustrate that this smooth SVM model improves in efficiency and accuracy compared with other smooth methods.

Workplace incivility remains a prevailing issue and has significant potential for harmful consequences. This study aims to investigate the influencing mechanism of workplace incivility on work alienation from the perspective of targets. Based on the social exchange theory, our research examines the role of interpersonal trust as a mediator along with the moderator of career resilience in the said association. Through a two-wave-time-lagged quantitative research design, a sample of 315 nurses from China was investigated with questionnaires on workplace incivility, work (...) alienation, interpersonal trust, and career resilience. The results indicated that workplace incivility was positively related to work alienation with interpersonal trust as a mediator. Workplace incivility caused a decline in interpersonal trust, which led to work alienation. Career resilience buffered such an impact. High career resilience weakened the association linking workplace incivility to interpersonal trust. Organizations should pay more attention to workplace incivility and consider empowering nurses’ career resilience, which could alleviate the negative impact of workplace incivility. (shrink)

Neurological diseases (NDs), featured by progressive dysfunctions of the nervous system, have become a growing burden for the aging populations. N‐Deacetylase and N‐sulfotransferase 3 (NDST3) is known to catalyze deacetylation and N‐sulfation on disaccharide substrates. Recently, NDST3 is identified as a novel deacetylase for tubulin, and its newly recognized role in modulating microtubule acetylation and lysosomal acidification provides fresh insights into ND therapeutic approaches using NDST3 as a target. Microtubule acetylation and lysosomal acidification have been reported to be critical for (...) activities in neurons, implying that the regulators of these two biological processes, such as the previously known microtubule deacetylases, histone deacetylase 6 (HDAC6) and sirtuin 2 (SIRT2), could play important roles in various NDs. Aberrant NDST3 expression or tubulin acetylation has been observed in an increasing number of NDs, including amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), schizophrenia and bipolar disorder, Alzheimer's disease (AD), and Parkinson's disease (PD), suggesting that NDST3 is a key player in the pathogenesis of NDs and may serve as a target for development of new treatment of NDs. (shrink)

本书分为唯物史观研究的一般问题、坚持唯物史的基本原理、社会及其进步问题、科学发展观与唯物史观的创新等七部分。.

Background: Contact heat evoked potentials is used to diagnose small fiber neuropathy. We established the normal values of CHEPs parameters in Chinese adults, optimized the test technique, and determined its reproducibility.Methods: We recruited 151 healthy adults. CHEPs was performed on the right forearm to determine the optimal number of stimuli, and then conducted at different sites to establish normal values, determine the effects of demographic characteristics and baseline temperature, and assess the short- and long-term reproducibility. N2 latency/height varied with age (...) and sex, while P2 latency/height and N2–P2 amplitude varied with age. The optimal number of stimuli was three.Results: N2 latency/height and P2 latency/height decreased and N2–P2 amplitude and visual analog scale score increased with increased baseline temperature. CHEPs parameters did not differ with time.Conclusion: We established normal CHEPs values in Chinese adults. We found that CHEPs parameters changed with baseline temperature and that the short- and long-term test reproducibility were satisfactory. (shrink)

EDITOR’S ABSTRACTThis paper discusses the Laozi from the perspective of the history of thought. Rather than trying to establish one correct edition and interpretation of Lao Zi’s work, Wang Bo traces the evolution from a political interpretation toward a more esoteric and life-cultivating reading. He shows how these different interpretations may have influenced the text itself. Focusing on differences between the recently acquired Peking University Han Bamboo Slips version and the transmitted edition, he analyzed two cases of remarkable variants: (...) the description of the Way as “profuse” versus “hidden,” and “having desire” versus “having the Way.”. (shrink)